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2912982 Stormo, Gary D.:
An Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics
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Einband: Hardcover
Auflage: 1. Auflage
Verlag: Cold Spring Harbor Laboratory Press New York
Erscheinungsdatum: 02/2013
Seiten: 150 pp
Abbildungen: illus., index

ISBN-10: 1-936113-49-X   
ISBN-13: 978-1-936113-49-1

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Beschreibung
One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. An Introduction to Protein–DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein–DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create unified view of the field and a fuller understanding of protein–DNA interactions.
Inhalt
Contents

(preliminary)
Preface
Chapter 1: Importance of Protein–DNA Interactions

Section I: Structure
Chapter 2: The Structure of DNA
Chapter 3: Protein Structure and DNA Recognition
Chapter 4: Sequence-specific Interactions in Protein–DNA Complexes

Section II: Biophysics
Chapter 5: Binding Affinity, Cooperativity, and Specificity
Chapter 6: Energetics and Kinetics of Binding

Section III: Bioinformatics and Computational Modeling
Chapter 7: Bioinformatics of DNA-binding Sites
Chapter 8: Bioinformatics of Transcription Factors and Recognition Models
Chapter 9: Bioinformatics of Gene Regulation
Subject Index

Zielgruppe/Leser
Bioinformatics
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