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2281076 Michael Klagsbrun; Patricia D'Amore:
Angiogenesis from Development to Pathology
  Preis:   € 72,00

Reihe: A Cold Spring Harbor Perspectives in Biology Collection, Einband: Hardcover
Auflage: 1.Auflage
Verlag: Cold Spring Harbor Laboratory Press New York
Erscheinungsdatum: 12/2011
Seiten: 400 pp. (approx.),
Abbildungen: illus., index

ISBN-10: 1-936113-43-0   
ISBN-13: 978-1-936113-43-9

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The generation of the vascular system is an important part of embryonic development. Formation of new blood vessels that supply growing tumors with nutrients is also an essential aspect of cancer progression. Work pioneered by researchers such as Judah Folkman, to whom this book is dedicated, has illuminated the mechanisms by which new blood vessels are produced and the vascular system as a whole is patterned. The contributors to this volume review our understanding of the mechanisms of angiogenesis, its role in cancer and other pathologies, as well as therapeutic approaches that target angiogenesis to combat these diseases.

1. Antiangiogenesis is Therapeutic for Retinopathies
Lloyd Aiello
2. Endothelial Cell Heterogeneity
William Aird
3. Lymphangiogenesis
Anil Bagri
4. VEGF-Directed Blood Vessel Patterning: From Cells to Organism
Victoria L. Bautch
5. Childhood Hemangioma
Joyce Bischoff and Shoshana Greenberger
6. Alpha V Integrins in Angiogenesis and Cancer
Sara M. Weis and David A. Cheresh
7. Myeloid Cells and Lymphangiogenesis
Adrian Zumsteg and Gerhard Christofori
8. Signal Transduction by Vascular Endothelial Growth Factor Receptors
Sina Koch and Lena Claesson-Welsh
9. Common Polymorphisms in Angiogenesis
Michael S. Rogers and Robert J. D’Amato
10. Endothelial Cell-to-Cell Junctions: Adhesion and Signaling in Physiology and Pathology
Elisabetta Dejana and Maria Grazia Lampugnani
11. Tumor Endothelial Cells
Andrew C. Dudley
12. Vascular Hyperpermeability, Angiogenesis, and Stroma Generation
Janice A. Nagy, Ann M. Dvorak, and Harold F. Dvorak
13. Molecular Parallels Between Neural and Vascular Development
Anne Eichmann
14. VEGF, Notch in Tip, and Stalk Cell Selection
Holger Gerhardt and Raquel Blanco
15. An Evaluation of Angiogenesis Inhibitors in the Clinic
Herbert Hurwitz
16. Vascular Normalization as a Therapeutic Strategy for Malignant and Non-Malignant Disease
Shom Goel, Andus Hon-Kit Wong, and Rakesh K. Jain
17. Angiogenic Factors in Preecclampsia and Related Disorders
Ana Sofia Cerdeira and S. Ananth Karumanchi
18. The VEGF Pathway in Cancer and Disease: Responses, Resistance, and the Path Forward
Mark W. Kieran, Raghu Kalluri, and Yoon-Jae Cho
19. Wnt Signaling in Angiogenesis
Jan Kitajewski
20. Vascular Lumen Formation
Eckhard Lammert and Jennifer Axnick
21. Molecular Basis for the Regulation of Angiogenesis by Thrombospondin-1 and -2
Patrick R. Lawler and Jack Lawler
22. Arteriovenous Malformations and Other Vascular Malformation Syndromes
Kevin J. Whitehead, Matthew C.P. Smith, and Dean Y. Li
23. miRNAs as Modulators of Angiogenesis
Shira Landskroner-Eiger, Isabelle Moneke, and William C. Sessa
24. The Complex Role of Angiopoietin-2 in the Angiopoietin-Tie Signaling Pathway
Gavin Thurston and Christopher Daly
25. Vasular Anomalies: From Genetics Toward Models for Therapeutic Trials
Melanie Uebelhoer, Laurence M. Boon, and Miikka Vikkula
26. The Role of the Tumor Microenvironment in Regulating Angiogenesis
Randolph S. Watnick
27. Vasular Development in the Zebrafish
Brant Weinstein
28. Human Endothelial Progenitor Cells
Mervin C. Yoder
29. PIGF
Peter Carmeliet and Leen Notebaert
30. Semaphorins in Angiogenesis and Tumor Progression
Gera Neufeld, Adi D. Sabag, Noa Rabinovicz, and Ofra Kessler


Michael Klagsbrun, Children's Hospital Boston;
Patricia D'Amore, Schepens Eye Research Institute
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