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Abate-Shen, Cory; Politi, Katerini; Chodosh, Lewis:
Mouse Models of Cancer: A Laboratory Manual
Preis:
€ 186,00
Einband: Hardcover
Auflage: 1. Auflage
Verlag: Cold Spring Harbor Laboratory Press New York
Erscheinungsdatum: 12/2013
Seiten: 500pp(appr.)
Abbildungen: illus, index
ISBN-10: 1-62182-004-1
ISBN-13: 978-1-621820-04-8
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Developmental Biology | Molekularbiologie | Onkologie |
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Beschreibung
The laboratory mouse is an important model for studying cancer and its treatment. This book includes both background information and step-by-step protocols for generating mouse models that accurately recapitulate many features of human cancer. It covers genetic models, including transgenic germline models, gene knockouts and knockins, and conditional and inducible systems, as well as models derived using chemical carcinogens, RNA interference, tissue recombination, and other strategies. Techniques to characterize tumor development, progression, and metastasis in these mice using state-of-the-art imaging, histopathological, surgical, and other approaches are described. The uses of these models in preclinical and translational research are also discussed.
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Inhalt
Contents
(Preliminary)
Preface
INTRODUCTION: Of Model Pets and Cancer Models
Andrea Lunardi, Caterina Nardella, Sean Clohessy, and Pier Paolo Pandolfi
PART 1: Origins and History of Mouse Models of Cancer
1. Transgenic Mouse Models – A Seminal Breakthrough in Oncogene Research
Harvey H. Smith and William J. Muller
2. Analyses of Tumor Suppressor Genes in Germ-line Mouse Models of Cancer
Jingqiang Wang and Cory Abate-Shen
3. Conditional Knock-out Mouse Models of Cancer
Chu-Xia Deng
4. Animal Models of Chemical Carcinogenesis: A 100-year Odyssey
Christopher J. Kemp
5. The Effects of Genetic Background of Mouse Models of Cancer: Friend or Foe?
Karlyne M. Reilly
PART 2: Recent Approaches to Modeling Cancer in Mice
6. Genetically Engineered Knock-in and Conditional Knock-in Mouse Models of Cancer A
Amy Rappaport and Leisa Johnson
7. Strategies to Achieve Conditional Gene Mutation in Mice
Jessica J. Gierut, Tyler E. Jacks, and Kevin M. Haigis
8. Tetracycline-Regulated Mouse Models of Cancer
Lewis Chodosh
9. The Switchable ER-Fusion System in Mouse Models
Jonathan Whitfield, Trevor Littlewood, Gerard Evan, and Laura Soucek
10. Using the RCAS-TVA System to Model Human Cancer in Mice
Brian Lewis
11. Transposon Insertional Mutagenesis Models of Cancer
Karen M. Mann, Nancy A. Jenkins, Neal G. Copeland, and Michael B. Mann
12. Accelerating Cancer Modeling with RNAi and Nongermline Genetically Engineered Mouse Models
Scott Lowe and Geulah Livshits
13. Mosaic Models in the Murine Hematopoietic System
Michael Hemann
14. Tissue Recombination Models for the Study of Epithelial Cancer
Yang Zong, Andrew S. Goldstein, and Owen N. Witte
15. Immunodeficient Mouse Models for Cancer Research
Leonard D. Shultz, Neal Goodwin, Fumihiko Ishikawa, and Dale L. Greiner
PART 3: Analyzing Mouse Cancer Phenotypes
16. Analysis of Mouse Model Pathology: A Primer for Studying GEM Pathobiology
Robert D. Cardiff, Claramae H. Miller, and Robert J. Munn
17. Reporter Alleles for Imaging
Scott K. Lyons, P. Stephen Patrick, and Kevin M. Brindle
18. Noninvasive Imaging of Tumor Burden and Molecular Pathways in Mouse Models of Cancer
Yuchuan Wang, Jen-Chieh Tseng, Yanping Sun, and Andrew L. Kung
19. Methods to Study Metastasis in Genetically Modified Mice
Farhia Kabeer, Levi J. Beverly, Guilaume Darrasse-Jèze, and Katrina Podsypanina
20. Methods for Analyses of the Immune System
Lauren J. Bayne and Robert H. Vonderheide
21. Analyses of Tumor Cells in Culture
Andrew D. Rhim, Martin Jechlinger, and Anil K. Rustgi
22. Translational Therapeutics in Genetically Modified Mouse Models of Cancer
Ken Olive and Katerina Politi
Appendices
Index
Zielgruppe/Leser
Molecular Biology; Developmental Biology; Cancer and Oncogenes
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