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2187583 Bissell, Mina J.; Polyak, Kornelia; Rosen, Jeffrey M.:
The Mammary Gland as an Experimental Model
  Preis:   € 75,00

Einband: Hardcover
Verlag: Cold Spring Harbor Laboratory Press
Erscheinungsdatum: 2011
Seiten: 550 S.
Abbildungen: illus., index

ISBN-10: 0-87969-906-X   
ISBN-13: 9780-87969-906-2


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Beschreibung
Studies of mammary gland biology are critically important given the prevalence of breast cancer in the population. There are many other reasons to study this organ, however. It represents an excellent model system for research into developmental mechanisms, gene regulation, tissue organization, hormonal action, secretion, and stem cell biology, revealing general principles that can be extended to other organs and tissues. Moreover, many in vitro, ex vivo, and in vivo techniques have been developed using the mammary gland model and may be applied to other systems. This book therefore provides valuable lessons for all cell, developmental, and cancer biologists.
Inhalt
(preliminary)
Preface

HISTORICAL BACKGROUND
Of Mice and Women: A Short History of Mouse Mammary Cancer Research with an Emphasis on the Paradigm Inspired by the Transplantation Method
Daniel Medina
A Compendium of the Mouse Mammary Tumor Biologist: From the Initial Observations in the House Mouse to the Development of Genetically Engineered Mice
Robert D. Cardiff and Nicholas Kenney

STATE OF THE SCIENCE/ART
Murine Mammary Epithelial Stem Cells: Discovery, Function, and Current Status
Jane E. Visvader and Gilbert H. Smith
Stem Cells in the Human Breast
Ole William Petersen and Kornelia Polyak
Hormone Action in the Mammary Gland
Cathrin Brisken and Bert O’Malley
Mammary Gland Growth Factors: Roles in Normal Development and in Cancer
Nancy E. Hynes and Christine J. Watson
Cell–Matrix Interactions in Mammary Gland Development and Breast Cancer
John Muschler and Charles H. Streuli
Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression
Pepper Schedin and Patricia J. Keeley
Oncogene and Tumor Suppressor Genes
Eva Y.H.P. Lee and William B. Muller
The Role of the Microenvironment in Mammary Gland Development and Cancer
Kornelia Polyak and Raghu Kalluri
Molecular Mechanisms Guiding Embryonic Mammary Gland Development
Pamela Cowin and John Wysolmerski
TGF-β Biology in Mammary Development and Breast Cancer
Harold Moses and Mary Helen Barcellos-Hoff
Mammary Remodeling
Zena Werb and Rama Khoka
Immune Components
Jeffrey Pollard and Lisa Coussens

SYSTEM BIOLOGY AND GENOMICS
Gene Expression Analysis
Charles M. Perou and Anne-Lise B&ostrike;rresen-Dale
Using Functional Genetics to Understand Breast Cancer Biology
Alan Ashworth and Rene Bernards
Chromatin Remodeling in Mammary Gland Differentiation and Breast Tumorigenesis
Tim H.-M. Huang and Manel Esteller
In Vivo Imaging in Cancer
John Condeelis and Ralph Weissleder
Summary
Mina Bissell

Zielgruppe/Leser
Zellbiologie
Cancer and Oncogenes
Developmental Biology

Autoreninfo
Mina J. Bissell, Lawrence Berkeley National Laboratory; Kornelia Polyak, Harvard Medical School;
Jeffrey M. Rosen, Baylor College of Medicine
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