Details

Sonenberg, Nahum; Matthews, Michael B.; Hershey, John W.B.:
Protein Synthesis and Translational Control
The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and genetic disorders including “ribosomopathies.” Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of protein synthesis and its control, from the genomic level to single-molecule analysis and single-cell imaging. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high-resolution structures of the translational machinery. They review the targets of translational control (e.g., initiation factors and mRNAs) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs (including microRNAs) are also covered. This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as developmental and neurobiologists, oncologists, virologists, and all those investigating human diseases associated with translation dysfunction.
Preis: € 0,00

Einband: Hardcover
Auflage: 1. Auflage
Verlag: Cold Spring Harbor Laboratory Press New York
Erscheinungsdatum: 2012
Abbildungen: illus., appendices, index

ISBN-10: 1-936113-46-5
ISBN-13: 9781936113460

Weitere Fachbücher aus dem Fachgebiet:
Biochemie | Genetik | Molekularbiologie |


zurück
Beschreibung The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and genetic disorders including “ribosomopathies.” Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of protein synthesis and its control, from the genomic level to single-molecule analysis and single-cell imaging. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high-resolution structures of the translational machinery. They review the targets of translational control (e.g., initiation factors and mRNAs) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs (including microRNAs) are also covered. This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as developmental and neurobiologists, oncologists, virologists, and all those investigating human diseases associated with translation dysfunction.

Inhalt
Contents

(preliminary)
1. Principles of Translational Control: An Overview
John W. B. Hershey, Nahum Sonenberg, and Michael B. Mathews
2. The Structure and Function of the Eukaryotic Ribosome
Daniel N. Wilson and Jamie H. Doudna Cate
3. The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges
Alan G. Hinnebusch and Jon R. Lorsch
4. The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes
Thomas E. Dever and Rachel Green
5. Single-Molecule Analysis of Translational Dynamics
Alexey Petrov, Jin Chen, Seán O’Leary, Albert Tsai, and Joseph D. Puglisi
6. The Current Status of Vertebrate Cellular mRNA IRESs
Richard J. Jackson
7. From cis-Regulatory Elements to Complex RNPs and Back
Fátima Gebauer, Thomas Preiss, and Matthias W. Hentze
8. Regulation of mRNA Translation by Signaling Pathways
Philippe P. Roux and Ivan Topisirovic
9. Protein Secretion and the Endoplasmic Reticulum
Adam M. Benham
10. New Insights into Translational Regulation in the Endoplasmic Reticulum Unfolded Protein Response
Graham D. Pavitt and David Ron
11. P Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation
Carolyn J. Decker and Roy Parker
12. mRNA Localization and Translational Control in Drosophila Oogenesis
Paul Lasko
13. Toward a Genome-Wide Landscape of Translational Control
Ola Larsson, Bin Tian, and Nahum Sonenberg
14. Imaging Translation in Single Cells Using Fluorescent Microscopy
Jeffrey A. Chao, Young J. Yoon, and Robert H. Singer
15. A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs
Joerg E. Braun, Eric Huntzinger, and Elisa Izaurralde
16. Translational Control in Cancer Etiology
Davide Ruggero
17. Cytoplasmic RNA Binding Proteins and Control of Complex Brain Function
Jennifer C. Darnell and Joel D. Richter
18. Tinkering with Translation: Protein Synthesis in Virus-Infected Cells
Derek Walsh, Michael B. Mathews, and Ian Mohr
19. Emerging Therapeutics Targeting mRNA Translation
Abba Malina, John R. Mills, and Jerry Pelletier

Zielgruppe/Leser
Genetics and Genome Science; Molecular Biology; Biochemistry

Buchtipps