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1732432 Leonard Guarente; Linda Partridge; Douglas Wallace:
Molecular Biology of Aging
Monograph 51; Series
Preis:   € 128,00

Einband: Hardcover
Verlag: Cold Spring Harbor Laboratory Press New York
Erscheinungsdatum: 2008
Seiten: 750pp.
Abbildungen: illus., index

ISBN-10: 0-87969-824-1   
ISBN-13: 978-087969824-9


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Beschreibung
Research into the causes of aging, and strategies to delay that process, have gained much ground and attention in recent years. This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer. Each chapter is written by one or more leaders in the field, and the book presents the current status of this exciting research area and provides an invaluable source of information in a single volume.
Inhalt
1. The Human Mitochondrion and the Pathophysiology of Aging and Age–related Diseases by D.C. Wallace
2. Sirtuins by L. Guarente and S. Imai
3. CR and Stress in Lower Organisms by S. Helfand
4. Evolutionary Theory by S. Austad and T. Kirkwood
5. An Overview of the Biology of Aging: A Human Perspective by G.M. Martin and C.E. Finch
6. p53, Cancer, and Longevity by L.A. Donehower and A.J. Levine
7. Aging Processes in Caenorhabditis elegans by H.A. Tissenbaum and T.E. Johnson
8. Senescence by J. Campisi and J. Sedivy
9. Genome–wide Views of Aging Gene Networks by S.K. Kim
10. Stem Cells by N. Sharpless
11. Drosophila by L. Partridge and J. Tower
12. DNA Repair and Aging by V.A. Bohr, D.M. Wilson, III, N.C. de Souza Pinto, I. van der Pluijm, and J.H. Hoeijmakers
13. Extended Lifespan in Mice with Reduction in the
GH/IGF–1 Axis by J.J. Kopchick, A. Bartke, and D.E. Berryman
14. Neurodegenerative Disease by D. Price and R.Tanzi
15. Calorie Restriction/Mammals by A. Richardson and R. Weindruch
16. Stress Tolerance by R. Miller and G. Lithgow
17. Yeast by S.–J. Lin and D. Sinclair
18. Human Longevityby T. Perls
19. Metazoan Models/Medicine by G. Ruvkun
20. Mammalian Metabolism by Puigserver and R. Kahn
21. Telomeres and Telomerase by Shay and W. Wright

Autoreninfo
Edited By Leonard Guarente, Massachusetts Institute of Technology, Cambridge; Linda Partridge, University College London, UK; Douglas Wallace, University of California, Irvine
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