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Beschreibung
Receptor tyrosine kinases are cell-surface receptors that respond to numerous hormones and growth factors, including insulin, insulin-like growth factors, epidermal growth factor, and nerve growth factor. They activate highly conserved intracellular signaling pathways that regulate cell proliferation, differentiation, and metabolism, playing essential roles in developing and adult animals. This book examines the nature of these receptors and their ligands, the molecular mechanisms that they regulate within cells, and the roles of the receptors in normal physiology and control of embryogenesis. It also discusses how dysfunction of these mechanisms can contribute to cancer and other diseases.
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Inhalt
Contents
(preliminary)
Preface
I. Introduction: Historical Perspectives
History of Receptor Tyrosine Kinases
Joseph Schlessinger and Mark A. Lemmon
II. Molecular Mechanistic Principles of RTK Signaling
Tyrosine Phosphorylation
Tony Hunter
The Insulin Receptor: Both a Prototypical and Typical Receptor Tyrosine Kinase
Stevan R. Hubbard
Structure-Function Relationships of ErbB RTKs in the plasma Membranes of Living Cells
Donna J. Arndt-Jovin and Thomas M. Jovin
Receptor Tyrosine Kinases in the Nucleus
Graham Carpenter and Hong-Jun Liao
III. Principles of Cellular Signaling by RTKs
Molecular Mechanisms of SH2- and PTB-Domain Containing Proteins in Receptor Tyrosine Kinase Signaling
Melany J. Wagner, Melissa M. Stacey, Bernard A. Liu, and Tony Pawson
Regulation of Receptor Tyrosine Kinase Ligand Processing
Colin Adrain and Matthew Freeman
Biological Function of Nuclear Receptor Tyrosine Kinase Action
Sungmin Song, Kenneth M. Rosen, and Gabriel Corfas
Endocytosis of Receptor Tyrosine Kinases
Lai Kuan Goh and Alexander Sorkin
Effects of Membrane Trafficking on Signaling by Receptor Tyrosine Kinases
Marta Miaczynska
Complexity of Receptor Tyrosine Kinase Signal Processing
Natalia Volinsky and Boris N. Kholodenko
IV. RTKs in Development
Receptor Tyrosine Kinases in Drosophila Development
Richelle Sopko and Norbert Perrimon
Biology of the TAM Receptors
Greg Lemke
V. Specific Characteristics of Key RTK Families Structural and Functional Properties of Platelet-Derived Growth Factor and Stem Cell Factor Receptors
Carl-Henrik Heldin and Johan Lennartsson
VEGFR and Type-V Receptor Tyrosine Kinase Activation and Signaling
Masabumi Shibuya
Advances in the Molecular Mechanisms of FGF Signaling in Physiology and Pathology
Artur A. Belov and Moosa Mohammadi
Structure and Physiology of the RET Receptor Tyrosine Kinase
Carlos F. Ibáñez
Tie2 and Eph Receptor Tyrosine Kinase Activation and Signaling
William A. Barton, Annamarie C. Dalton, Tom C.M. Seegar, Juha P. Himanen, and Dimitar B. Nikolov
Eph Receptor Signaling and Ephrins
Erika M. Lisabeth, Giulia Falivelli, and Elena B. Pasquale
The Role of MuSK in Synapse Formation and Neuromuscular Disease
Steven J. Burden, Norihiro Yumoto, and Wei Zhang
The Role of Ryk and Ror Receptor Tyrosine Kinases in Wnt Signal Transduction
Roel Nusse, Jennifer Green, and Renée van Amerongen
VI. RTKS in Disease and Medicine
Receptor Tyrosine Kinase-Mediated Angiogenesis
Michael Jeltsch, Veli-Matti Leppänen, Pipsa Saharinen, and Kari Alitalo
Insulin Receptor Signaling in Normal and Insulin Resistant States
Jérémie Boucher, André Kleinridders, and C. Ronald Kahn
MET: A Critical Player in Tumorigenesis and Therapeutic Target
Carrie R. Graveel, David Tolbert, and George F. Vande Woude
Central Role of RET in Thyroid Cancer
Massimo Santoro and Francesca Carlomagno
Index
Zielgruppe/Leser
Cell Biology; Molecular Biology; Developmental Biology
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