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2912986 Riordan, John R.; Boucher, Richard C.; Quinton, Paul M.:
Cystic Fibrosis: A Trilogy of Biochemistry, Physiology, and Pathology
  Preis:   € 69,80

Reihe: Perspective in Biology, Einband: Hardcover
Auflage: 1. Auflage
Verlag: Cold Spring Harbor Laboratory Press New York
Erscheinungsdatum: 07/2013
Seiten: 400 pp.(approx.),
Abbildungen: approx. 37 4C; 11 B&W

ISBN-10: 1-936113-34-1   
ISBN-13: 978-1-936113-34-7


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Beschreibung
Cystic fibrosis is a respiratory disease cause by mutations in the chloride transporter CFTR. This book examines the role of CFTR in the lung airway epithelium, the effects of CFTR mutations that lead to cystic fibrosis, and novel therapeutic approaches to combating the disease.
Inhalt
Contents

(preliminary)
Preface

Molecular Basis
The Cystic Fibrosis Gene: A Molecular Genetic Perspective
Lap-Chee Tsui and Ruslan Dorfman
Assessing the Disease-Liability of Mutations in CFTR
Claude Ferec and Garry R. Cutting
The CFTR Ion Channel
Tzyh-Chang Hwang and Kevin L. Kirk
CFTR Structure
John Hunt and Robert Ford
Dynamics Intrisic to CFTR Function and Stability
P. Andrew Chong, Pradeep Kota, Nikolay V. Dokholyan, and Julie D. Forman-Kay
CFTR Folding and Cellular Processing
Phillip Thomas and Gergely Lukacs
The Influence of Genetics on CF Phenotypes
Michael R. Knowles and Mitchell Drumm

Physiological Changes
Status of Fluid and Electrolyte Absorption in Cystic Fibrosis
M. M. Reddy and J. Stutts
Physiology of Epithelial Chloride and Fluid Secretion
Raymond A. Frizzell and John W. Hanrahan
Mechanisms of Bicarbonate Secretion: Lessons from the Airways
Robert J. Bridges
Transepithelial Bicarbonate Secretion: Lessons from the Pancreas
Hyun Woo Park and Min Goo Lee
Mucin Overproduction and Mucus Obstruction in Cystic Fibrosis
Silvia Kreda, C. William Davis, and Mary Callaghan Rose
Polymer Gel Physics of Mucus
Pedro Verdugo
Perspectives on Mucus Properties and Formation––Lessons from the Biochemical World
Daniel Ambort, Malin E.V. Johnsson, Jenny K. Gustafsson, Anna Ermund, and Gunnar C. Hansson

Therapeutic Strategies
Mucus Clearance in the Lungs
Brenda Button and Brian Button
The CF Microbiome
Susan Lynch
The CF of Exocrine Pancreas
Michael Wilchanski and Ivana Novak
The CF Intestine
Robert C. De Lisle and Drucy Borowitz
Antibiotics and Anti-inflammation
Michael Konstan and James Chmiel
Non-CFTR-Directed Pulmonary Therapies
S. Donaldson and L. Galietta
CFTR Correctors and Potentiators
Steven M. Rowe and A.S. Verkman
Index

Zielgruppe/Leser
Humanbiologie
Biochemie
Pathologie
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