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2717431 Bluestone, Jeffrey A.; Atkinson, MArk A.; Arvan, Peter R.:
Type 1 Diabetes
  Preis:   € 69,00

Einband: Hardcover
Auflage: 1. Auflage
Verlag: Cold Spring Harbor Laboratory Press New York
Erscheinungsdatum: 2012
Seiten: 300 pp. (approx.), index

ISBN-10: 1-936113-21-X   
ISBN-13: 9781936113217


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Beschreibung
Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing β cells in the pancreas by the body’s immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of glucose dysregulation. Written by experts in the field, this book provides a detailed examination of our understanding of the disease process and its causes, as well as a genetic risk factors, animal models or diabetes, and new treatment strategies that are being developed.
Inhalt
Contents

Preliminary
1. The Pathogenesis and Natural History of Type 1 Diabetes
Mark A. Atkinson
2. Islet Autoantigens: Structure, Function, Localization, and Regulation
Peter Arvan, Massimo Pietropaolo, David Ostrov, and Christopher J. Rhodes
3. The Unfolded Protein Response in Beta-Cell Survival
Feroz Papa
4. Generating Beta-Cells from Stem Cells—The Story so Far
Matthias Hebrok
5. Virus Infections in Type 1 Diabetes
Ken T. Coppieters, Tobias Boettler, and Matthias von Herrath
6. Environmental Triggers of Type 1 Diabetes
Mikael Knip and Olli Simell
7. Methods, prediction and the effect of therapy of genetic, immunologic and metabolic Biomarkers of β cell destruction in the diagnosis of T1D
Jasmin Lebastchi and Kevan C. Herold
8. Clinical Interventions for the Treatment of T1D
Lucienne Chatenoud, Katharina Warncke, and Annette G. Ziegler
9. Connecting Type 1 and Type 2 Diabetes Through Innate Immunity
Justin I. Odegaard and Ajay Chawla
10. Genetics of Type 1 Diabetes
Janelle A. Noble and Henry A. Erlich
11. Humoral Autoimmunity and the Prediction of Type-1 Diabetes
Massimo Pietropaolo, Roberto Towns, and George S. Eisenbarth
12. Advancing Animal Models of Human Type 1 Diabetes by Engraftment of Functional Human Tissues in Immunodeficient Mice
Michael A. Brehm, Alvin C. Powers, Leonard D. Shultz, and Dale L. Greiner
13. Do MHCII-Presented Neo-Antigens Drive Type-1 Diabetes and Other Autoimmune Diseases?
Philippa Marrack and John W. Kappler
14. Antigen-Specific Therapeutic Approaches in Type 1 Diabetes
Xavier Clement-Casares, Sue Tsai, Carol Huang, and Pere Santamaria
15. Antigen Targets of Type 1 Diabetes Autoimmunity
Bart O. Roep and Mark Peakman
16. The Hygiene Hypothesis: An Explanation for the Increased Frequency of Insulin-Dependent Diabetes
Jean-François Bach and Lucienne Chatenoud
17. Breakdown in Peripheral Tolerance in Type 1 Diabetes
Lukas T. Jeker, Hélène Bour-Jordan, and Jeffrey A. Bluestone
18. Update on Islet Transplantation
Michael McCall and A. M. James Shapiro
Index

Zielgruppe/Leser
Human Biology & Disease
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