Inhalt
Contents
I. Chemistry and Biology of Proteostasis
Physical Biochemistry of Protein Folding and Misfolding
Michele Vendruscolo, Tuomas P. J. Knowles, and Christopher M. Dobson
Integrating Protein Homeostasis Strategies in Prokaryotes
Axel Mogk, Damon Huber, and Bernd Bukau
Cellular Strategies of Protein Quality Control
Bryan Chen, Marco Retzlaff, Thomas Roos, and Judith Frydman
Integration of Clearance Mechanisms: The Proteasome and Autophagy
Esther Wong and Ana Maria Cuervo
Aging as an Event of Proteostasis Decline
Rebecca C. Taylor and Andrew Dillin
The Stress of Protein Misfolding: From Single Cells to Multicellular Organisms
Tali Gidalevitz, Veena Prahlad, and Richard I. Morimoto
II. Protein Quality Control in Cellular Compartments
Protein Folding in the Cytoplasm and the Heat Shock Response
Martin Vabulas, Swasti Raychaudhuri, Manajit Hayer-Hartl, and F. Ulrich Hartl
Protein folding and quality control in the ER
Kazutaka Araki and Kazuhiro Nagata
Stress and its Functional Link to Mitochondria: Role in Cell Survival and Death
Jyoti D. Malhotra and Randy Kaufman
Quality Control of Mitochondrial Proteostasis
Michael J. Baker, Takashi Tatsuta, and Thomas Langer
III. Disorders of Protein Homeostasis
Hepatic Fibrosis and Carcinogenesis in Alpha-1-Antitrypsin Deficiency: A Prototype For Chronic Tissue Damage in Gain-of-Function Disorders
David H. Perlmutter and Gary A. Silverman
Alzheimer Disease
Dennis J. Selkoe
Huntingtons’ Disease
Steven Finkbeiner
Proteostasis and Movement Disorders: Parkinson’s Disease and Amyotrophic Lateral Sclerosis
Daryl A. Bosco, Matthew J. LaVoie, Gregory A. Petsko, and Dagmar Ringe
Prions
David W. Colby and Stanley B. Prusiner
Emergent Properties of Proteostasis in Managing Cystic Fibrosis
William E. Balch, Daniela Roth, and Darren M. Hutt
Protein Misfolding and Retinal Degeneration
Radouil Tzekov, Linda Stein, and Shalesh Kaushal
Chemical and Biological Approaches for Adapting Proteostasis to Ameliorate Protein Misfolding and Aggregation Diseases–Progress and Prognosis
Susan L. Lindquist and Jeffery W. Kelly
Index
Zielgruppe/Leser
Cell Biology
Biochemistry
Autoreninfo
Richard I. Morimoto, Northwestern University; Dennis J. Selkoe, Brigham and Women's Hospital; Jeffrey W. Kelly, Scripps Institute
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CRISPR-Cas:
Budding Yeast
Learning and Memory
Conservation Science: Balancing the Needs of People and Nature
Introduction to Optical Microscopy
Organic Chemistry
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