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Beschreibung This volume is based on presentations by the world-renowned investigators who gathered at the 75th annual Cold Spring Harbor Symposium on Quantitative Biology to discuss the organization and function of the cell nucleus. It reviews the latest advances in research into nuclear structure, the organization of the genome within the nucleus, and spatiotemporal coordination of nuclear processes. The topics examined include nuclear domains, chromatin organization, transcription and RNA processing, DNA replication, nuclear reprogramming, and epigenetics. Cancer, premature aging syndromes, and other diseases that may be associated with altered nuclear organization are also covered.
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Inhalt (preliminary)
Foreword
INTRODUCTION
John B. Gurdon, Rob Martienssen, Barbara J. Meyer, and Gunter Blobel
CHROMATIN MODIFICATIONS AND GENE EXPRESSION
John T. Lis, Danny Reinberg, Shelley Berger, C. David Allis, Steven Henikoff, Robert E. Kingston, and Gary Felsenfeld
DNA REPLICATION AND GENOME INTEGRITY
John Diffley, David M. Gilbert, Geneviève Almouzni, Bruce Stillman, Titia de Lange, Camilla Sjögren, and Craig L. Peterson
REPROGRAMMING AND DIFFERENTIATION
Rudolf Jaenisch, Azim Surani, Ken Zaret, Richard A. Young, Huck H. Ng, D.P. Bazett-Jones, and Tom Misteli
RNA BIOLOGY
Joseph G. Gall, Joan A. Steitz, Ramin Shiekhattar, Edith Heard, Jeanne B. Lawrence, and Sui Huang
CHROMOSOME STRUCTURE AND MITOSIS
Kim Nasmyth, Luis Aragon, Stephen C. Harrison, Don W. Cleveland, Yoshinori Watanabe, Tim Stearns, and William C. Earnshaw
HETEROCHROMATIN FORMATION AND GENE SILENCING
Shiv I. Grewal, Robin C. Allshire, Craig S. Pikaard, Nicholas J. Proudfoot, and Angelika Amon
TRANSCRIPTION MEETS RNA PROCESSING
Stephen Buratowski, Alberto R. Kornblihtt, Pamela A. Silver, A. Gregory Matera, Robert H. Singer, and Lynne E. Maquat
NUCLEAR PERIPHERY
Bas van Steensel, Robert D. Goldman, Roland Foisner, Susan M. Gasser, Michael P. Rout, and Martin W. Hetzer
CHROMATIN STRUCTURE AND ORGANIZATION
Daniela Rhodes, Andrew S. Belmont, Thomas Cremer, Rolf Ohlsson, Peter Fraser, and David L. Spector
GENOME REGULATION
Wendy Bickmore, Giacomo Cavalli, Ingrid Grummt, and Stephen B. Baylin
SUMMARY
Steven Henikoff
Author Index
Zielgruppe/Leser Zellbiologie
Genetik
Onkologie
Molekularbiologie
Autoreninfo Terri Grodzicker, Cold Spring Harbor Laboratory; David Spector, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory
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