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3538113 Olshansky, S. Jay; Martin, George M.; Kirkland, James L:
Aging: The Longevity Dividend
  Preis:   € 125,00

Reihe: A Cold Spring Harbor Perspectives in Medicine Collection, Einband: Hardcover
Auflage: 1.Auflage
Verlag: Cold Spring Harbor Laboratory Press New York
Erscheinungsdatum: 12/2015
Seiten: 300 pages (approx.)
Abbildungen: illustrated (approximately 26 combined 4 color & B&W), index

ISBN-10: 1-62182-080-7   
ISBN-13: 9781621820802


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Allgemeinmedizin | Genetik | Humanbiologie | 
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Beschreibung
Aging affects us all and is characterized not only by increasing frailty but by increased susceptibility to conditions such as Alzheimer’s, cardiovascular disease, and cancer. We are gaining an increasing understanding of the molecular mechanisms underlying aging, however, and uncovering clues to how life may be prolonged. This book examines the biological basis of aging and research into strategies that may extend lifespan
Inhalt
(preliminary)
The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Healthspan and Lifespan
Felipe Sierra
Part One: Basic Mechanisms of Biological Aging
An Overview of the Theory of Aging
Steven Austad
Cell Senescence
Judith Campisi
The Role of the Microenvironmental Niche in Declining Stem Cell Functions Associated with Biological Aging
Nathan A. DeCarolis, Elizabeth D. Kirby, Tony Wyss-Coray, and Theo D. Palmer
Biochemical Genetic Pathways that Modulate Aging in Multiple Species
Alessandro Bitto, Adrienne M. Wang, Christopher F. Bennett, and Matt Kaeberlein
Mitochondrial Dysfunction and Aging
Douglas Wallace
DNA Damage, DNA Repair, Aging, and Neurodegeneration
Scott Maynard, Evandro Fei Fang, Morten Scheibye-Knudsen, Deborah L. Croteau, and Vilhelm A. Bohr
How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend Initiative
Fuki M. Hisama, Junko Oshima, and George M. Martin
Dissecting the Mechanisms Underlying Successful Human Healthspan and Lifespan
Sofiya Milman and Nir Barzilai
Proteostasis and Aging
Gordon Lithgow
The Companion Dog as a Model for the Longevity Dividend
Kate E. Creevy, Steven N. Austad, Jessica M. Hoffman, Dan G. O’Neill, and Daniel E.L. Promislow
Part Two: Clinical and Translational Aspects of Aging
The Translation of Aging Science into a Therapeutic Intervention
James L. Kirkland
Human Frailty
Linda Fried
The Aging Heart
Ying Ann Chiao and Peter S. Rabinovitch
Inhibition of the Mechanistic Target of Rapamycin (mTOR)—Rapamycin and Beyond
Dudley W. Lamming
Metformin: A Hopeful Promise in the Aging Research
Marta G. Novelle, Ahmed Ali, Carlos Dieguez, Michel Bernier, and Rafael de Cabo
Part Three: Societal Implications of Delayed Aging
Articulating the Case for the Longevity Dividend
S. Jay Olshansky
The Economic Promise of Delayed Aging
Dana Goldman
Past, Present, and Future of Healthy Life Expectancy
Hiram Beltrán-Sánchez, Samir Soneji, and Eileen M. Crimmins
Has the Rate of Human Aging Already Been Modified?
S. Jay Olshansky
Index

Zielgruppe/Leser
HUman Anatomy, Genetics, Diseases
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