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2281078 Dennis J. Selkoe; David M. Holtzman; Eckhard Mandelkow:
The Biology of Alzheimer Disease
  Preis:   € 69,00

Reihe: A Cold Spring Harbor Perspectives in Biology Collection, Einband: Hardcover
Auflage: 1.Auflage
Verlag: Cold Spring Harbor Laboratory Press New York
Erscheinungsdatum: 12/2011
Seiten: 375 pp. (approx.)
Abbildungen: illus., index

ISBN-10: 1-936113-44-9   
ISBN-13: 978-1-936113-44-6


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Beschreibung
Alzheimer Disease represents an important area of research in neurobiology, cell biology, developmental biology and pathology. Understanding the nature of the changes that occur in neurons as the disease progresses — accumulation of amyloid beta and neurofibrillary tangles — is obviously important as we try to develop therapeutic approaches. Moreover, the normal physiological roles of proteins such as APP and tau, whose processing appears to be altered in Alzheimer’s, is also an intense area of research
Inhalt
Contents

(preliminary)
1. Introduction: Deciphering Alzheimer Disease
Dennis Selkoe, David Holtzman, and Eckhard Mandelkow
2. The Clinical Problem of Symptomatic Alzheimer Disease and Mild Cognitive Impairment
John C. Morris
3. The Neuropsychological Profile of Alzheimer Disease
Sandra Weintraub, Alissa H. Wicklund, and David P. Salmon
4. Neuropathological Alterations in Alzheimer Disease
Alberto Serrano-Pozo, Matthew P. Frosch, Eliezer Masliah, and Bradley T. Hyman
5. Brain Imaging in Alzheimer Disease
Keith A. Johnson, Nick C. Fox, Reisa A. Sperling, and William E. Klunk
6. Fluid Biomarkers in Alzheimer Disease
Kaj Blennow, Henrik Zetterberg, Anne M. Fagan
7. Epidemiology of Alzheimer Disease
Richard Mayeux and Yaakov Stern
8. Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration
Eva Mandelkow and Eckhard Mandelkow
9. Frontotemporal Dementia: Implications for understanding Alzheimer Disease
Michel Goedert, Bernardino Ghetti, and Maria Grazia Spillantini
10. Biochemistry of Amyloid Deposition in Alzheimer Disease
Colin L. Masters and Dennis J. Selkoe
11. Trafficking and Proteolytic Processing of APP
Christian Haass, Christoph Kaether, Sam Sisodia, Gopal Thinakaran
12. Physiological Functions of APP Family Proteins
Ulrike C. Müller and Hui Zheng
13. The Genetics of Alzheimer Disease: APP, Presenilin, Apolipoprotein E, and the Search for Other Genes
Rudolph E. Tanzi and Peter St. George-Hyslop
14. Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease
Bart De Strooper, Takeshi Iwatsubo, and Michael S. Wolfe
18. Inflammation in Alzheimer’s Disease—A Brief Review of the Basic Science and Clinical Literature
Tony Wyss-Coray and Joseph Rogers
19. The Ubiquitin-Proteasome System and Autophagy in Alzheimer Disease
Yasuo Ihara and Ralph Nixon
20. Transport, Clearance, and Proteolytic Degradation of Amyloid β-Protein
Takaomi Saido
21. Treatment Strategies Targeting Beta Amyloid Peptide
Dale Schenk
22. Developing Therapeutic Approaches to Tau, Selected Kinases, and Related Neuronal Protein Targets
Virginia M-Y. Lee, Kurt R. Brunden, Michael Hutton, and John Q. Trojanowski
23. Symptomatic and Non-Amyloid/Tau Based Pharmacologic Treatment for Alzheimer Disease
Paul S. Aisen, Jeffrey L. Cummings, and Lon S. Schneider
24. Alzheimer Disease in 2020
David Holtzman, Dennis J. Selkoe, and Eckhard Mandelkow

Zielgruppe/Leser
Biologie
Neurowissenschaften

Autoreninfo
Dennis J. Selkoe, Brigham and Women’s Hospital;
David M. Holtzman, Washington University School of Medicine;
Eckhard Mandelkow, Max-Planck-Unit for Structural Molecular Biology
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