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Beschreibung
Aging is one of the greatest challenges currently facing society. People are living longer than ever, but many of the later years are fraught with frailty and disease, placing enormous burden on health-care systems. Understanding the biological changes that occur during aging and developing strategies to address them are therefore urgently needed.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biological basis of aging, strategies that may extend health span, and the societal implications of delayed aging. Contributors discuss genetic variants that accelerate or protect against aging, biochemical pathways that modulate longevity (e.g., mTOR), biological consequences of aging (e.g., decline in stem cell function), and various animal models used to study aging processes. They emphasize that age-delaying interventions will yield greater health and vitality than disease-specific treatments. Drugs that may promote health span or longevity (e.g., metformin) and efforts to prevent and treat frailty (e.g., through exercise) are explored.
The authors consider the socioeconomic benefits and costs of delayed aging and also outline directions for future research and translational efforts. This volume will serve as a vital reference for all involved in the fields of geroscience and geriatric medicine, as well as anyone wishing to understand physiological processes that generate health and disease, regardless of chronological age.
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Inhalt
Contents
(preliminary)
The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Healthspan and Lifespan
Felipe Sierra
Part One: Basic Mechanisms of Biological Aging
An Overview of the Theory of Aging
Steven Austad
Cell Senescence
Judith Campisi
The Role of the Microenvironmental Niche in Declining Stem Cell Functions Associated with Biological Aging
Nathan A. DeCarolis, Elizabeth D. Kirby, Tony Wyss-Coray, and Theo D. Palmer
Biochemical Genetic Pathways that Modulate Aging in Multiple Species
Alessandro Bitto, Adrienne M. Wang, Christopher F. Bennett, and Matt Kaeberlein
Mitochondrial Dysfunction and Aging
Douglas Wallace
DNA Damage, DNA Repair, Aging, and Neurodegeneration
Scott Maynard, Evandro Fei Fang, Morten Scheibye-Knudsen, Deborah L. Croteau, and Vilhelm A. Bohr
How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend Initiative
Fuki M. Hisama, Junko Oshima, and George M. Martin
Dissecting the Mechanisms Underlying Successful Human Healthspan and Lifespan
Sofiya Milman and Nir Barzilai
Proteostasis and Aging
Gordon Lithgow
The Companion Dog as a Model for the Longevity Dividend
Kate E. Creevy, Steven N. Austad, Jessica M. Hoffman, Dan G. O’Neill, and Daniel E.L. Promislow
Part Two: Clinical and Translational Aspects of Aging
The Translation of Aging Science into a Therapeutic Intervention
James L. Kirkland
Human Frailty
Linda Fried
The Aging Heart
Ying Ann Chiao and Peter S. Rabinovitch
Inhibition of the Mechanistic Target of Rapamycin (mTOR)—Rapamycin and Beyond
Dudley W. Lamming
Metformin: A Hopeful Promise in the Aging Research
Marta G. Novelle, Ahmed Ali, Carlos Dieguez, Michel Bernier, and Rafael de Cabo
Part Three: Societal Implications of Delayed Aging
Articulating the Case for the Longevity Dividend
S. Jay Olshansky
The Economic Promise of Delayed Aging
Dana Goldman
Past, Present, and Future of Healthy Life Expectancy
Hiram Beltrán-Sánchez, Samir Soneji, and Eileen M. Crimmins
Has the Rate of Human Aging Already Been Modified?
S. Jay Olshansky
Index
Zielgruppe/Leser
Aging Research; Human Biology and Disease; Genetics
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Introduction to Optical Microscopy
Organic Chemistry
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