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2717432 Przedborski, Serge:
Parkinson's Disease
  Preis:   € 59,80

Einband: Hardcover
Auflage: 1. Auflage
Verlag: Cold Spring Harbor Laboratory Press New York
Erscheinungsdatum: 2012
Seiten: 300 pp. (approx.), index

ISBN-10: 1-936113-32-5   
ISBN-13: 978-1-936113-32-3


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Beschreibung
Parkinson’s Disease is an incurable neurodegenerative disease characterized by a progressive loss of dopaminergic neurons that leads to slowness of movement, muscle rigidity, and tremors. Insoluble aggregates of proteins such as alpha-synuclein accumulate in the affected neurons, which also appear to be subject to oxidative stress. This volume discusses recent work that has begun to uncover the molecular mechanisms that underlie the condition, including studies that implicate dysfunction of mitochondrial proteins such as parkin and pink1.
Inhalt
Contents

Preliminary
1. Introduction
Serge Przedborski
2. The History of Parkinson’s Disease: Early Clinical Descriptions and Neurological Therapies
Christopher G. Goetz
3. Clinical Approach to Parkinson’s Disease: Features, Diagnosis, and Principles of Management
João Massano and Kailash P. Bhatia
4. Genetics of Parkinson’s Disease
Christine Klein and Ana Djarmati
5. Neuropathy
Dennis Dickson
6. Chemical Neuroanatomy
Jose Angel Obeso Inchausti
7. Functional Neuroimaging in Parkinson’s Disease
Martin Niethammer, Andrew Feigin, and David Eidelberg
8. Motor Control Abnormalities in Parkinson’s Disease
Pietro Mazzoni, Britne Shabbott, and Juan Camilo Cortes
9. Psysiological Phenotypes and Vulnerability in Parkinson’s Disease
D. James Surmeier, Jaime N. Guzman, Javier Sanchez, and Paul T. Schumacker
10. Modeling Parkinson’s Disease in Primates: The MPTP Model
Gregory Porras, Qin Li, and Erwan Bezard
11. A Guide to Neurotoxic Animal Models of Parkinson’s Disease
Kim Tieu
12. Animal Models: Vertebrate Genetics
Ted M. Dawson, Valina Dawson, and Yujong Lee
13. Animal Models: Invertebrate
Ming Guo
14. Mitochondrial Biology and Parkinson’s Disease
Celine Perier and Miquel Vila
15. Autophagy
Gary Buettner
16. The Role of Autophagy in Parkinson’s Disease
Melinda A. Lynch-Day, Kai Mao, Ke Wang, Mantong Zhao, and Daniel J. Klionsky
17. Programmed Cell Death
Katerina Venderova and David Park
18. Innate Inflammation in Parkinson’s Disease
V. Hugh Perry
19. Inflammation and Adaptive Immunity in Parkinson’s Disease
R. Lee Mosely, Jessica A. Hutter-Saunders, David K. Stone, and Howard E. Gendelman
20. Alpha-Synuclein in Parkinson’s Disease
Leonidas Stefanis
21. LRRK2 for Beginners: Six Key Questions
Lauren R. Kett and William T. Dauer
22. Parkinsonism due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitrochondrial Pathways
Mark R. Cookson
23. Protein Quality Control in Parkinson’s Disease
Casey Cook, Caroline Stetler, and Leonard Petrucelli
24. Parkinson’s Disease: Gene Therapies
Phillippe Coune, Bernard L. Schneider, and Patrick Aebischer
25. Bioinformatics
Howard Federoff
Index

Zielgruppe/Leser
Human Biology & Disease
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