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2187578 Tessier-Lavigne, Marc; Kolodkin, Alex L.:
Neuronal Guidance: The Biology of Brain Wiring(Cold Spring Harbor Perspectives in Biology)
   Preis:   € 53,50

Einband: Hardcover
Verlag: Cold Spring Harbor Laboratory Press
Erscheinungsdatum: 12/2010
Seiten: 330 S.
Abbildungen: illus., index

ISBN-10: 0-87969-897-7   
ISBN-13: 9780-87969-897-3

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Beschreibung
Neuronal guidance is a critical mechanism during the development of the nervous system. The developing neuron responds to cues from its surroundings that influence the direction in which it grows and ultimately the connections it makes with its targets. These cues can be attractive or repulsive and are provided by both soluble and cell-surface molecules (e.g. netrins and ephrins, respectively). Receptors on the surface of the neuronal growth cones bind to these cues, relaying intracellular signals that ultimately result in cytoskeletal rearrangements that cause the growing axon to extend toward and away from the source of the cue. The field thus sits at the interface of cell, developmental and neurobiology, and tremendous progress has been made in our understanding of it in recent years.
Inhalt
(preliminary)
Preface
Introduction: Principles and Molecules Governing Neural Process Guidance and Branching
Alex L. Kolodkin and Marc Tessier-Lavigne

AXON GUIDANCE AND BRANCHING STRATEGIES
Cellular Strategies of Axonal Pathfinding
Jonathan Raper and Carol Mason
Navigating Intermediate Targets: The Nervous System Midline
Barry J. Dickson and Yimin Zou
Motor Axon Pathfinding
Dario Bonanomi and Samuel L. Pfaff
Molecular and Cellular Mechanisms of Lamina-specific Axon Targeting
Andrew D. Huberman, Tom R. Clandinin, and Herwig Baier
Self-avoidance and Tiling: Mechanisms of Dendrite and Axon Spacing
Wesley B. Grueber and Alvaro Sagasti
Visual Map Development: Bidirectional Signaling, Bifunctional Guidance Molecules, and Competition
David A. Feldheim and Dennis D.M. O’Leary
Topographic Mapping—The Olfactory System
Takeshi Imai, Hitoshi Sakano, and Leslie B. Vosshall
Wiring the Brain: The Biology of Neuronal Guidance
Alain Chédotal and Linda J. Richards
Human Genetic Disorders of Axon Guidance
Elizabeth C. Engle

CELL BIOLOGY OF AXON GROWTH, GUIDANCE, AND BRANCHING
Initiating and Growing an Axon
Franck Polleux and William Snider
How the Growth Cone Moves during Axon Outgrowth and Guidance
Frank Gertler and Erik Dent
Rho and Ras GTPases in Axon Growth, Guidance, and Branching
Alan Hall and Giovanna Lalli
Signaling from Axon Guidance Receptors
Greg J. Bashaw and Rüdiger Klein
Trafficking Guidance Receptors
Bettina Winckler and Ira Mellman

BEYOND AXONS—INVOLVEMENT OF GUIDANCE STRATEGIES AND MOLECULES IN RELATED PROCESSES
Guiding Neuronal Cell Migrations
Oscar Marín, Manuel Valiente, Xuecai Ge, and Li-Huei Tsai
Guidance Molecules in Synapse Formation and Plasticity
Kang Shen and Christopher W. Cowan
Guidance Molecules in Axon Pruning and Cell Death
Pierre Vanderhaeghen and Hwai-Jong Cheng
Guidance Molecules in Axon Regeneration
Roman J. Giger, Edmund R. Hollis II, and Mark H. Tuszynski
Axon Guidance Molecules in Vascular Patterning
Ralf H. Adam and Anne Eichmann

Index

Zielgruppe/Leser
Zellbiologie
Developmental Biology
Neurobiologie

Autoreninfo
Marc Tessier-Lavigne, Genentech, Inc.;
Alex L. Kolodkin, Howard Hughes Medical Institute, The Johns Hopkins University, Baltimore
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